rs10911021 - LINC01344
Magnitude 2.8 · 1 study on file
Reported associations
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Association Between a Genetic Variant Related to Glutamic Acid Metabolism and Coronary Heart Disease in Type 2 Diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 23982368
ABSTRACT: IMPORTANCE Diabetes is associated with an elevated risk of coronary heart disease (CHD). Previous studies have suggested that the genetic factors predisposing to excess cardiovascular risk may be different in diabetic and non-diabetic participants. OBJECTIVE To identify genetic determinants of CHD that are specific to diabetic patients. DESIGN, SETTING, AND PARTICIPANTS We studied five independent sets of CHD cases and CHD-negative controls from the Nurses Health Study (NHS; enrolled in 1976 and followed through 2008), Health Professionals Follow-up Study (HPFS; enrolled in 1986 and followed through 2008), Joslin Heart Study (enrolled in 2001-2008), Gargano Heart Study (enrolled in 2001-2008), and Catanzaro Study (enrolled in 2004-2010). Included were a total of 1,517 CHD cases a
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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CHD risk assessment given genetic susceptibility High
C allele carriers with type 2 diabetes have 36 percent increased coronary heart disease risk due to reduced GLUL expression affecting glutathione antioxidant pathways.
Discuss variant status and screening options with your doctor during diabetes care.