Expressive

rs10906100 - CDC123

Magnitude 2.2 · 1 study on file

Reported associations

  • Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 36329257

    ABSTRACT: To explore the complex genetic architecture of common diseases and traits, we conducted comprehensive PheWAS of ten diseases and 34 quantitative traits in the community-based Taiwan Biobank (TWB). We identified 995 significantly associated loci with 135 novel loci specific to Taiwanese population. Further analyses highlighted the genetic pleiotropy of loci related to complex disease and associated quantitative traits. Extensive analysis on glycaemic phenotypes (T2D, fasting glucose and HbA1c) was performed and identified 115 significant loci with four novel genetic variants (HACL1, RAD21, ASH1L and GAK). Transcriptomics data also strengthen the relevancy of the findings to metabolic disorders, thus contributing to better understanding of pathogenesis. In addition, genetic risk sc

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • refined carbohydrates and high-glycemic foods Moderate

    Refined carbohydrates cause rapid glucose spikes; limiting them helps individuals with variants affecting glucose metabolism maintain better control.

    Replace refined grains with whole grains; limit added sugars and processed foods

Lifestyle

  • regular physical activity for glucose control Moderate

    Exercise improves insulin sensitivity and glucose homeostasis, mitigating the elevated glucose associated with this variant.

    Aim for 150 minutes of moderate-intensity aerobic activity per week

Screening

  • fasting glucose and HbA1c levels Moderate

    This variant is associated with elevated fasting glucose and HbA1c levels, indicating increased diabetes risk.

    Check annually or as recommended by healthcare provider