rs10905716 - RPL32P23 - RBM17

Magnitude 2.0 · 1 study on file

Reported associations

• Plasma levels of sIL-2Rα: associations with clinical cardiovascular events and genome- wide association scan - Arteriosclerosis, thrombosis, and vascular biology (2015) · Durda P, Sabourin J, Lange EM, Nalls MA, Mychaleckyj JC, Jenny NS, Li J, Walston J, Harris TB, Psaty BM, Valdar W, Liu Y, Cushman M, Reiner AP, Tracy RP, Lange LA · PubMed 26293465

  ABSTRACT: Objective Interleukin-2 receptor subunit alpha (IL-2Rα) regulates lymphocyte activation, which plays an important role in atherosclerosis. Associations between soluble IL-2Rα and cardiovascular disease (CVD) have not been widely studied and little is known about the genetic determinants of sIL-2Rα levels. Approach and Results We measured baseline levels of sIL- 2Rα in 4408 European-American (EA) and 766 African-American (AA) adults from the Cardiovascular Health Study (CHS) and examined associations with baseline CVD risk factors, subclinical CVD and incident CVD events. We also performed a genome-wide association study (GWAS) for sIL-2Rα in CHS (2964 EAs and 683 AAs) and further combined CHS EA results with those from two other EA cohorts in a meta-analysis (N=4464 EAs). In

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