Expressive

rs10905480 - LINC02676

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genomic skin cancer risk counseling with dermatology High

    Strong GWAS evidence at this locus warrants professional risk assessment and personalized surveillance planning.

    Discuss findings with dermatologist; establish baseline risk profile and tailored screening and prevention schedule

Lifestyle

  • Daily sun protection High

    Variant carriers show 8.5% increased odds of skin cancer per effect allele; photoprotection is the primary modifiable prevention strategy.

    Daily SPF 30+ broad-spectrum sunscreen, UV-protective clothing, seek shade 10am-4pm, avoid indoor tanning beds

Screening

  • Annual dermatologic skin cancer screening High

    LINC02676 rs10905480 risk allele A is strongly associated with increased skin cancer susceptibility, necessitating enhanced surveillance.

    Annual full-body skin examination by dermatologist, starting age 20-25 or earlier if family history present