rs10901091 - RAPGEF1 - EIF4A1P3

Magnitude 2.2 · 1 study on file

Reported associations

• A Genome-Wide Association Study of α-Synuclein Levels in Cerebrospinal Fluid. - Neurotoxicity research (2019) · Zhong XL, Li JQ, Sun L, Li YQ, Wang HF, Cao XP, Tan CC, Wang L, Tan L, Yu JT · PubMed 29959729

  α-Synuclein is a 140-amino acid protein produced predominantly by neurons in the brain which plays a role in the regulation of neurotransmitter release, synaptic function, and plasticity, thus making it the focus in understanding the etiology of a group of neurodegenerative diseases. We conducted genome-wide association studies (GWAS) of α-synuclein levels in cerebrospinal fluid (CSF) with 209 non-Hispanic white participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI-1) cohort using a linear regression model to identify novel variants associated with α-synuclein concentration. The minor allele (T) of rs7072338 in the long intergenic non-protein coding RNA 1515 (LINC01515) and the minor allele (T) of rs17794023 in clusterin-associated protein 1 (CLUAP1) were associated wi

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