rs10900522 - NUCKS1

Magnitude 2.0 · 1 study on file

Reported associations

• Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits - Unknown journal (n.d.) · Unknown authors · PubMed 30289880

  ABSTRACT: Genome-wide association studies have shown that pleiotropy is a common phenomenon that can potentially be exploited for enhanced detection of susceptibility loci. We propose heritability informed power optimization (HIPO) for conducting powerful pleiotropic analysis using summary-level association statistics. We find optimal linear combinations of association coefficients across traits that are expected to maximize non-centrality parameter for the underlying test statistics, taking into account estimates of heritability, sample size variations and overlaps across the traits. Simulation studies show that the proposed method has correct type I error, robust to population stratification and leads to desired genome-wide enrichment of association signals. Application of the proposed m

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