rs10899500 - GAB2
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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kidney function monitoring strategy Moderate
Genetic predisposition to reduced glomerular filtration rate warrants individualized monitoring plan
Lifestyle
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blood pressure control Moderate
Hypertension accelerates kidney function decline in genetically predisposed individuals
Target blood pressure below 120/80 mmHg or per doctor recommendation
Screening
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kidney function assessment Moderate
rs10899500-T allele associated with lower eGFR across 571k individuals; early detection enables intervention
Annual blood pressure, serum creatinine, and eGFR assessment