rs10897597 - TENM4 - RNU6-544P

Magnitude 2.0 · 1 study on file

Reported associations

• Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness - Communications biology (2024) · Amelink JS, Postema MC, Kong XZ, Schijven D, Carrión-Castillo A, Soheili-Nezhad S, Sha Z, Molz B, Joliot M, Fisher SE, Francks C · PubMed 39342056

  ABSTRACT: Language is supported by a distributed network of brain regions with a particular contribution from the left hemisphere. A multi-level understanding of this network requires studying its genetic architecture. We used resting-state imaging data from 29,681 participants (UK Biobank) to measure connectivity between 18 left-hemisphere regions involved in multimodal sentence-level processing, as well as their right-hemisphere homotopes, and interhemispheric connections. Multivariate genome-wide association analysis of this total network, based on genetic variants with population frequencies  >1%, identified 14 genomic loci, of which three were also associated with asymmetry of intrahemispheric connectivity. Polygenic dispositions to lower language-related abilities, dyslexia and left

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