rs10897526 - MAP4K2
Magnitude 2.2 · 1 study on file
Reported associations
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Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484
ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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purine-rich meats and organ meats Moderate
High dietary purine intake is converted to uric acid; limiting purine sources reduces serum uric acid.
Limit red meat and organ meats to 2-3 times per week; minimize shellfish
Lifestyle
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alcohol, especially beer Moderate
Alcohol intake increases uric acid production; beer contains purines.
Limit to 1 drink or fewer per day; avoid beer
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daily water intake Moderate
Adequate hydration promotes renal excretion of uric acid, lowering serum levels.
Drink 2-3 liters of water daily; more if exercising
Screening
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serum uric acid level Moderate
This SNP is associated with elevated serum uric acid, a risk factor for gout and chronic kidney disease.
Check every 1-2 years if asymptomatic; annually if symptomatic