rs10896430 - TPCN2

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-Wide Association Study of Incident Dementia in a Community-Based Sample of Older Subjects - Unknown journal (n.d.) · Unknown authors · PubMed 35694926

  ABSTRACT: Background: Alzheimer's disease (AD) is a complex disease influenced by the environment and genetics; however, much of the genetic component remains unaccounted for. Objective: The purpose of this work was to use genome-wide association analyses to detect genetic associations with incident AD in a sample of older adults aged 75 and above. Methods: We performed a genome-wide association study (GWAS) on genome-wide genotyped and imputed data (14,072,053 variants) on the Gingko Evaluation of Memory (GEM) study sample consisting of 424 incident dementia (mean age = 84.46±3.91) and 2,206 non-demented (mean age = 84.55±3.23) subjects. Results: The established association of APOE*4 carriers with AD was confirmed in this community-based sample of older subjects (odds ratio (O

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