Expressive

rs10896373 - CPT1A - LINC02701

Magnitude 2.2 · 2 studies on file

Reported associations

  • The power of genetic diversity in genome-wide association studies of lipids - Unknown journal (n.d.) · Unknown authors · PubMed 34887591

    ABSTRACT: Elevated blood lipid levels are heritable risk factors of cardiovascular disease with varying prevalence worldwide due to differing dietary patterns and medication use. Despite advances in prevention and treatment, particularly through the lowering of low-density lipoprotein cholesterol levels, heart disease remains the leading cause of death worldwide. Genome-wide association studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS have been conducted in European ancestry populations and may have missed genetic variants contributing to lipid level variation in other ancestry groups due to differences in allele frequencies, effect sizes, and linkage-disequilibr

  • New role of fat-free mass in cancer risk linked with genetic predisposition - Unknown journal (n.d.) · Unknown authors · PubMed 38538606

    ABSTRACT: Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 individuals. Using this dataset, a comprehensive analysis using regression, principal component and genome-wide genetic association, provided multiple levels of evidence that increasing whole body fat (WBFM) and fat-free mass (WBFFM) are both associated with increased post-menopausal breast cancer risk, and colorectal cancer risk in men. WBFM was inversely associated with prostate cancer. We also identified rs615029[T] and rs1485995[G] as associated in independent analyses with both PMB

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • triglyceride levels Moderate

    T allele at rs10896373 associated with elevated triglycerides in large GWAS

    Baseline test; repeat annually if normal, more frequently if elevated

Diet

  • limit refined carbohydrates and added sugars Moderate

    T allele raises triglyceride baseline; refined carbs increase triglycerides further

    Replace refined grains with whole grains; limit sugary drinks

Discuss with your doctor

  • triglyceride management strategies Moderate

    T allele associated with elevated triglycerides; professional guidance on management recommended

Exercise

  • aerobic exercise Moderate

    Aerobic exercise reduces triglycerides; particularly important given triglyceride-elevating variant

    150 minutes of moderate-intensity aerobic exercise per week