Expressive

rs10895901 - KBTBD3

Magnitude 2.2 · 1 study on file

Reported associations

  • Genomics and phenomics of body mass index reveals a complex disease network - Unknown journal (n.d.) · Unknown authors · PubMed 36581621

    ABSTRACT: Elevated body mass index (BMI) is heritable and associated with many health conditions that impact morbidity and mortality. The study of the genetic association of BMI across a broad range of common disease conditions offers the opportunity to extend current knowledge regarding the breadth and depth of adiposity-related diseases. We identify 906 (364 novel) and 41 (6 novel) genome-wide significant loci for BMI among participants of European (N~1.1 million) and African (N~100,000) ancestry, respectively. Using a BMI genetic risk score including 2446 variants, 316 diagnoses are associated in the Million Veteran Program, with 96.5% showing increased risk. A co-morbidity network analysis reveals seven disease communities containing multiple interconnected diseases associated with BMI

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Structured macronutrient balance for weight management Moderate

    eQTL data shows rs10895901 variant regulates gene expression in adipose tissue; dietary quality impacts adipose function and metabolic homeostasis

    Mediterranean or DASH-style dietary pattern; track macronutrient composition

Discuss with your doctor

  • BMI trajectory and metabolic risk assessment Moderate

    rs10895901-G associated with increased BMI; individualized metabolic risk assessment helps guide prevention strategies

Exercise

  • Regular aerobic and resistance exercise Moderate

    Physical activity is the primary behavioral intervention for BMI management; genetic predisposition to higher BMI increases benefit of structured exercise

    150 min/week moderate aerobic exercise plus 2x/week resistance training

Screening

  • Body mass index and metabolic screening Moderate

    rs10895901-G carrier status is associated with increased BMI; metabolic monitoring identifies early cardiovascular and glucose tolerance complications

    Annual BMI, lipid panel, fasting glucose; more frequent if BMI trending upward