rs10895022 - ARHGAP42
Magnitude 2.2 · 1 study on file
Reported associations
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High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941
ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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blood pressure management targets given genetic predisposition Moderate
Individuals with this genetic variant may benefit from earlier or more aggressive BP management to reduce cardiovascular disease risk
Screening
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blood pressure measurement Moderate
rs10895022 T allele associated with 0.273 mmHg systolic increase in 526,001 individuals; eQTL effects in vascular tissues suggest direct vascular mechanism
annual measurement at minimum; consider quarterly if baseline systolic > 120 mmHg