rs10891790 - NXPE2 - CADM1
Magnitude 2.2 · 1 study on file
Reported associations
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The power of genetic diversity in genome-wide association studies of lipids - Unknown journal (n.d.) · Unknown authors · PubMed 34887591
ABSTRACT: Elevated blood lipid levels are heritable risk factors of cardiovascular disease with varying prevalence worldwide due to differing dietary patterns and medication use. Despite advances in prevention and treatment, particularly through the lowering of low-density lipoprotein cholesterol levels, heart disease remains the leading cause of death worldwide. Genome-wide association studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS have been conducted in European ancestry populations and may have missed genetic variants contributing to lipid level variation in other ancestry groups due to differences in allele frequencies, effect sizes, and linkage-disequilibr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Fasting lipid panel with triglyceride measurement Moderate
rs10891790 A allele associated with elevated triglyceride levels, a cardiovascular risk factor
Annual fasting lipid panel; increase frequency if triglycerides elevated
Diet
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Reduce refined carbohydrates and added sugars Moderate
Refined carbohydrates increase triglyceride production, directly relevant to rs10891790-associated elevation
Minimize refined grains and sugary foods; emphasize whole grains and complex carbohydrates
Exercise
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Regular aerobic physical activity Moderate
Aerobic exercise reduces triglycerides, a primary intervention for rs10891790-A carriers
150 minutes moderate-intensity aerobic activity per week minimum