Expressive

rs10890020 - RN7SKP19 - LINC01360

Magnitude 2.2 · 3 studies on file

Reported associations

  • Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study - Unknown journal (n.d.) · Unknown authors · PubMed 32473944

    ABSTRACT: Highlights Observational studies of the role of inflammation on self-harm have conflicting results. We used Mendelian Randomisation, a novel causal inference technique to explore this. Genetic liability for high levels of IL-6 were not associated with self-harm. We found some evidence that higher levels of CRP were protective for self-harm. This potential protective effect of CRP has also been found for schizophrenia. Background The causal role of inflammatory markers on self-harm and suicidal risk has been studied using observational data, with conflicting results. Confounding and reverse causation can lead to bias, so we appraised question from a genetic perspective to protect against these biases. We measured associations between genetic liability for high levels of inflammato

  • Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions - Unknown journal (n.d.) · Unknown authors · PubMed 30718901

    ABSTRACT: Major depression is a debilitating psychiatric illness that is typically associated with low mood and anhedonia. Depression has a heritable component that has remained difficult to elucidate with current sample sizes due to the polygenic nature of the disorder. To maximise sample size, we meta-analysed data on 807,553 individuals (246,363 cases and 561,190 controls) from the three largest genome-wide association studies of depression. We identified 102 independent variants, 269 genes, and 15 gene-sets associated with depression, including both genes and gene-pathways associated with synaptic structure and neurotransmission. An enrichment analysis provided further evidence of the importance of prefrontal brain regions. In an independent replication sample of 1,306,354 individuals

  • Genetic diversity fuels gene discovery for tobacco and alcohol use - Unknown journal (n.d.) · Unknown authors · PubMed 36477530

    ABSTRACT: Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries. Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in s

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