Expressive

rs10889350 - DOCK7

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci - Unknown journal (n.d.) · Unknown authors · PubMed 34503513

    ABSTRACT: Background Genetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase the risk of cardiovascular and metabolic diseases. However, how changes in individual lipid species contribute to disease risk is often unclear. Moreover, little is known about the role of lipids on cardiovascular disease in Pakistan, a population historically underrepresented in cardiovascular studies. Methods We characterised the genetic architecture of the human blood lipidome in 5662 hospital controls from the Pakistan Risk of Myocardial Infarction Study (PROMIS) and 13,814 healthy British blood donors from the INTERVAL study. We applied a candidate causal gene prioritisation tool to link the genetic variants associated with each lipid to the most likely

  • Genetic architecture of routinely acquired blood tests in a British South Asian cohort - Unknown journal (n.d.) · Unknown authors · PubMed 39414775

    ABSTRACT: Understanding the genetic basis of routinely-acquired blood tests can provide insights into several aspects of human physiology. We report a genome-wide association study of 42 quantitative blood test traits defined using Electronic Healthcare Records (EHRs) of ~50,000 British Bangladeshi and British Pakistani adults. We demonstrate a causal variant within the PIEZO1 locus which was associated with alterations in red cell traits and glycated haemoglobin. Conditional analysis and within-ancestry fine mapping confirmed that this signal is driven by a missense variant - chr16-88716656-G-TT - which is common in South Asian ancestries (MAF 3.9%) but ultra-rare in other ancestries. Carriers of the T allele had lower mean HbA1c values, lower HbA1c values for a given level of random or

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • dietary fiber and unsaturated fats Moderate

    Fiber and unsaturated fats lower non-HDL cholesterol; T allele carriers have baseline elevation

    Target 25-35g fiber daily; emphasize plant oils, nuts, fish, whole grains, legumes

Exercise

  • regular cardiovascular exercise Moderate

    Aerobic exercise lowers non-HDL cholesterol; T allele carriers benefit from proactive effort

    150 minutes moderate intensity or 75 minutes vigorous aerobic activity weekly

Screening

  • non-HDL cholesterol levels Moderate

    T allele is associated with elevated non-HDL cholesterol, a recognized cardiovascular risk factor

    Annual lipid panel; discuss target goals with your doctor