rs10888177 - LPL - RPL30P9
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration - Unknown journal (n.d.) · Unknown authors · PubMed 31719535
ABSTRACT: Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lip
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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sleep duration of 7-9 hours nightly Moderate
rs10888177 shows interaction with sleep duration on HDL cholesterol; adequate sleep may optimize lipid profile effects
aim for 7-9 hours consistent sleep per night
Screening
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HDL cholesterol level Moderate
rs10888177 in LPL region affects HDL cholesterol with effects sensitive to sleep duration
annual lipid panel