rs10886369 - LINC03036
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways - Unknown journal (n.d.) · Unknown authors · PubMed 36050321
ABSTRACT: The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for ce
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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serum potassium, magnesium, and calcium Moderate
electrolyte imbalances can prolong QT interval and increase arrhythmia risk
periodic monitoring per cardiologist recommendation
Discuss with your doctor
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QT interval status and medication interactions Moderate
risk allele increases QT interval; certain medications can prolong QT further and increase arrhythmia risk
Screening
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baseline and periodic ECG Moderate
variant is associated with QT interval prolongation, which increases arrhythmia risk
baseline ECG, then per cardiologist recommendation