rs10881475 - VAV3

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders - The British journal of psychiatry : the journal of mental science (2017) · Coleman JR, Lester KJ, Keers R, Roberts S, Curtis C, Arendt K, Bögels S, Cooper P, Creswell C, Dalgleish T, Hartman CA, Heiervang ER, Hötzel K, Hudson JL, In-Albon T, Lavallee K, Lyneham HJ, Marin CE, Meiser-Stedman R, Morris T, Nauta MH, Rapee RM, Schneider S, Schneider SC, Silverman WK, Thastum M, Thirlwall K, Waite P, Wergeland GJ, Breen G, Eley TC · PubMed 26989097

  ABSTRACT: Background Anxiety disorders are common, and cognitive-behavioural therapy (CBT) is a first-line treatment. Candidate gene studies have suggested a genetic basis to treatment response, but findings have been inconsistent. Aims To perform the first genome-wide association study (GWAS) of psychological treatment response in children with anxiety disorders (n = 980). Method Presence and severity of anxiety was assessed using semi-structured interview at baseline, on completion of treatment (post-treatment), and 3 to 12 months after treatment completion (follow-up). DNA was genotyped using the Illumina Human Core Exome-12v1.0 array. Linear mixed models were used to test associations between genetic variants and response (change in symptom severity) immediately post-treatment and at

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