rs10879261 - TSPAN8
Magnitude 2.2 · 1 study on file
Reported associations
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Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925
ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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refined carbohydrates and added sugars Moderate
TSPAN8 rs10879261 risk alleles increase type 2 diabetes susceptibility; restricting refined carbohydrates is a primary diabetes prevention strategy
limit added sugars to 25 grams daily, prioritize whole grains
Exercise
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aerobic physical activity for diabetes prevention Moderate
Carriers of TSPAN8 rs10879261 risk alleles have elevated type 2 diabetes risk; regular aerobic exercise reduces this risk
150 minutes moderate-intensity aerobic activity per week
Screening
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fasting glucose and hemoglobin A1c Moderate
rs10879261 risk alleles confer elevated type 2 diabetes risk
annual testing starting at age 25