Expressive

rs10878674 - LINC02421 - LINC01479

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association analysis of actigraphic sleep phenotypes in the LIFE Adult Study. - Journal of sleep research (2017) · Spada J, Scholz M, Kirsten H, Hensch T, Horn K, Jawinski P, Ulke C, Burkhardt R, Wirkner K, Loeffler M, Hegerl U, Sander C · PubMed 27126917

    The genetic basis of sleep is still poorly understood. Despite the moderate to high heritability of sleep-related phenotypes, known genetic variants explain only a small proportion of the phenotypical variance. However, most previous studies were based solely upon self-report measures. The present study aimed to conduct the first genome-wide association (GWA) of actigraphic sleep phenotypes. The analyses included 956 middle- to older-aged subjects (40-79 years) from the LIFE Adult Study. The SenseWear Pro 3 Armband was used to collect 11 actigraphic parameters of night- and daytime sleep and three parameters of rest (lying down). The parameters comprised measures of sleep timing, quantity and quality. A total of 7 141 204 single nucleotide polymorphisms (SNPs) were analysed after imputa

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • daytime sleepiness and sleep disorder evaluation Moderate

    GWAS association with daytime sleep phenotypes warrants clinical assessment for underlying sleep quality issues.

    Discuss sleep quality, daytime alertness, and screening for sleep apnea if appropriate.

Lifestyle

  • consistent sleep schedule and sleep duration optimization Moderate

    Maintaining stable sleep patterns may mitigate genetic predisposition to daytime sleepiness.

    Maintain consistent sleep-wake times; target 7-9 hours nightly.

Screening

  • daytime sleepiness and alertness Moderate

    rs10878674 is associated with daytime sleep phenotypes, indicating increased predisposition to daytime sleepiness or fragmented sleep quality.

    Track episodes of daytime sleepiness; discuss persistent symptoms with physician.