Expressive

rs10878340 - LRRK2

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association analysis of actigraphic sleep phenotypes in the LIFE Adult Study. - Journal of sleep research (2017) · Spada J, Scholz M, Kirsten H, Hensch T, Horn K, Jawinski P, Ulke C, Burkhardt R, Wirkner K, Loeffler M, Hegerl U, Sander C · PubMed 27126917

    The genetic basis of sleep is still poorly understood. Despite the moderate to high heritability of sleep-related phenotypes, known genetic variants explain only a small proportion of the phenotypical variance. However, most previous studies were based solely upon self-report measures. The present study aimed to conduct the first genome-wide association (GWA) of actigraphic sleep phenotypes. The analyses included 956 middle- to older-aged subjects (40-79 years) from the LIFE Adult Study. The SenseWear Pro 3 Armband was used to collect 11 actigraphic parameters of night- and daytime sleep and three parameters of rest (lying down). The parameters comprised measures of sleep timing, quantity and quality. A total of 7 141 204 single nucleotide polymorphisms (SNPs) were analysed after imputa

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic risk for daytime sleep phenotypes Moderate

    Genetic variant associated with daytime sleep phenotypes warrants clinical assessment of underlying sleep disorders.

    Discuss daytime sleepiness and sleep quality with primary care physician during next visit.

Lifestyle

  • Daytime sleepiness and sleep quality Moderate

    rs10878340 A-allele carriers show genome-wide significant association with daytime sleep phenotypes.

    Track sleep duration, sleep onset time, and daytime sleepiness episodes for awareness.

Screening

  • Sleep disorder screening Moderate

    Daytime sleep phenotype may indicate sleep apnea, narcolepsy, or other sleep disorders requiring clinical evaluation.

    Request sleep apnea screening questionnaire or formal sleep study if daytime sleepiness is confirmed.