Expressive

rs1087782 - TYW3 - LHX8

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association study of obstructive sleep apnoea in the Million Veteran Program uncovers genetic heterogeneity by sex. - EBioMedicine (2023) · Sofer T, Kurniansyah N, Murray M, Ho YL, Abner E, Esko T, Huffman JE, Cho K, Wilson PWF, Gottlieb DJ · PubMed 36989840

    Genome-wide association studies (GWAS) for obstructive sleep apnoea (OSA) are limited due to the underdiagnosis of OSA, leading to misclassification of OSA, which consequently reduces statistical power. We performed a GWAS of OSA in the Million Veteran Program (MVP) of the U.S. Department of Veterans Affairs (VA) healthcare system, where OSA prevalence is close to its true population prevalence. We performed GWAS of 568,576 MVP participants, stratified by biological sex and by harmonized race/ethnicity and genetic ancestry (HARE) groups of White, Black, Hispanic, and Asian individuals. We considered both BMI adjusted (BMI-adj) and unadjusted (BMI-unadj) models. We replicated associations in independent datasets, and analysed the heterogeneity of OSA genetic associations across HARE and sex

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Regular cardiovascular exercise Moderate

    Aerobic exercise enhances respiratory muscle function and reduces OSA severity in genetically at-risk individuals.

    Perform 150 minutes moderate-intensity aerobic activity weekly.

Lifestyle

  • Alcohol and sedatives before sleep Moderate

    Alcohol and sedating medications relax pharyngeal muscles and suppress respiratory drive in OSA-susceptible individuals.

    Avoid alcohol and sedative medications 3-4 hours before bedtime.

  • Lateral sleep positioning Moderate

    Side sleeping reduces airway collapse risk during sleep in genetically predisposed OSA carriers.

    Maintain side-lying position or use positional therapy device during sleep.

Screening

  • Obstructive sleep apnea evaluation High

    Genetic variant rs1087782 associated with significantly increased OSA risk independent of BMI adjustment.

    Discuss OSA screening options (home sleep test or in-lab study) with healthcare provider.