rs10877091 - RPL21P103 - LINC02388
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914
Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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insomnia risk from genetic variant Moderate
rs10877091 T allele associated with increased insomnia susceptibility in large GWAS study.
Review family sleep history and personal sleep patterns with healthcare provider
Screening
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sleep onset latency and sleep quality Moderate
Genetic predisposition warrants proactive monitoring for early detection of sleep disturbance.
Track sleep timing, duration, and daytime symptoms; discuss concerns with clinician if changes occur