Expressive

rs10875606 - KCTD16

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetic determinants of daytime napping and effects on cardiometabolic health - Unknown journal (n.d.) · Unknown authors · PubMed 33568662

    ABSTRACT: Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide association study of self-reported daytime napping in the UK Biobank (n = 452,633) and identify 123 loci of which 61 replicate in the 23andMe research cohort (n = 541,333). Findings include missense variants in established drug targets for sleep disorders (HCRTR1, HCRTR2), genes with roles in arousal (TRPC6, PNOC), and genes suggesting an obesity-hypersomnolence pathway (PNOC, PATJ). Association signals are concordant with accelerometer-measured daytime inactivity duration and 33 loci colocalize with loci for other sleep phenotypes. Cluster analysis identifies three distinct clusters of nap-promoting mech

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • daytime napping patterns and sleep quality Moderate

    Genetic KCTD16 variants increase napping susceptibility; habitual napping causally increases hypertension and adiposity.

Lifestyle

  • limit daytime napping frequency and duration Moderate

    Daytime napping causally increases blood pressure and central adiposity; KCTD16 variants increase napping propensity.

    Aim to avoid naps; if needed, limit to under 20 minutes. Prioritize 7-9 hours nighttime sleep.

Screening

  • blood pressure annually Moderate

    KCTD16 variants increase daytime napping frequency; daytime napping causally increases blood pressure; genetic risk requires monitoring.

    Establish baseline BP; repeat annually or per provider guidance

  • waist circumference and BMI Moderate

    Daytime napping causally associates with increased abdominal adiposity; KCTD16 variants increase napping frequency.

    Measure annually and assess trend; discuss with provider if rising