rs10875423 - FAM135B

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-wide association study of chronic periodontitis in a general German population. - Journal of clinical periodontology (2014) · Teumer A, Holtfreter B, Völker U, Petersmann A, Nauck M, Biffar R, Völzke H, Kroemer HK, Meisel P, Homuth G, Kocher T · PubMed 24024966

  To identify loci associated with chronic periodontitis through a genome-wide association study (GWAS). A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n = 3365 and SHIP-TREND n = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome-based autosomal and X-chromosomal genotypes and short insertions and deletions (INDELs) was performed in both cohorts. Finally, more than 17 million SNPs and short INDELs were analysed. No genome-wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not

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