rs10869462 - CARNMT1-AS1
Magnitude 2.2 · 1 study on file
Reported associations
-
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
-
serum magnesium levels Moderate
This variant is associated with magnesium metabolism disorders and altered magnesium levels.
Annual serum magnesium testing; more frequent if symptomatic (muscle weakness, cramping, fatigue)
Diet
-
magnesium-rich foods Moderate
Genetic variation affecting magnesium metabolism may benefit from consistent dietary magnesium sources.
Include daily: leafy greens, nuts, seeds, whole grains, legumes targeting 300-400 mg magnesium per day
Supplements
-
magnesium supplementation Moderate
The risk allele is associated with lower magnesium and magnesium metabolism disorders, suggesting impaired homeostasis.
If serum magnesium is low, discuss with healthcare provider; consider 200-400 mg/day magnesium glycinate or citrate