rs10867331 - MTND2P8 - KRT18P24

Magnitude 2.2 · 1 study on file

Reported associations

• Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19 related gene for global cognitive function - Unknown journal (n.d.) · Unknown authors · PubMed 37089073

  ABSTRACT: INTRODUCTION: Cognitive abilities have substantial heritability across life as shown by twin and population- based studies. However, there is limited understanding of genetic factors related to cognitive decline in aging across neurocognitive domains. METHODS: We conducted meta-analysis on 3045 individuals aged ≥65, derived from three population-based cohorts, to identify genetic variants associated with decline of five neurocognitive domains (attention, memory, executive function, language, visuospatial function) and global cognitive decline. We also conducted gene-based and functional bioinformatics analyses. RESULTS: APOE*4 was significantly associated with decline of memory (P=5.58E-09) and global cognitive function (P=1.84E-08). We identified a novel association with atten

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