Expressive

rs10866845 - EBF2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • adequate dietary fiber to reduce constipation Moderate

    EBF2 rs10866845 increases hernia risk; chronic straining from constipation elevates intra-abdominal pressure

    25-35g fiber daily from whole grains, legumes, vegetables, and fruits

Discuss with your doctor

  • discuss inguinal hernia risk and prevention with clinician Moderate

    EBF2 rs10866845 C allele carriers have 1.17-fold increased inguinal hernia risk

Lifestyle

  • heavy lifting and straining Moderate

    EBF2 rs10866845 increases hernia risk; heavy lifting increases intra-abdominal pressure

    use proper lifting mechanics; seek assistance for loads over 25 lbs

Screening

  • periodic clinical screening for inguinal hernia Moderate

    EBF2 rs10866845 increases hernia risk; early detection enables intervention

    annual abdominal exam with clinician; self-monitor for groin swelling or pain