rs10866713 - IL12B-AS1
Magnitude 2.2 · 1 study on file
Reported associations
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Genomewide meta-analysis identifies novel multiple sclerosis susceptibility loci - Unknown journal (n.d.) · Unknown authors · PubMed 22190364
ABSTRACT: Objective To perform a one-stage meta-analysis of genome-wide association studies (GWAS) of multiple sclerosis (MS) susceptibility and explore functional consequences of new susceptibility loci. Methods We synthesized 7 MS GWAS. Each dataset was imputed using HapMap phase II and a per-SNP meta-analysis was performed across the 7 datasets. We explored RNA expression data using a quantitative trait analysis in peripheral blood mononuclear cells (PBMCs) of 228 subjects with demyelinating disease. Results We meta-analyzed 2,529,394 unique SNPs in 5,545 cases and 12,153 controls. We identified three novel susceptibility alleles: rs170934T at 3p24.1 (OR=1.17, P = 1.6 × 10−8) near EOMES, rs2150702G in the second intron of MLANA on chromosome 9p24.1 (OR = 1.16, P = 3.3 × 10−8), and
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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MS risk assessment based on genetic finding Low
The A allele at rs10866713 in IL12B is associated with increased multiple sclerosis risk through dysregulation of IL-12 inflammatory signaling
Discuss with healthcare provider; consider baseline neurological evaluation if family history of MS present