rs10865419 - PNPP1 - USP21P2

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic architecture of age-related cognitive decline in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 28078323

  ABSTRACT: Objective: To identify genetic risk factors associated with susceptibility to age-related cognitive decline in African Americans (AAs). Methods: We performed a genome-wide association study (GWAS) and an admixture-mapping scan in 3,964 older AAs from 5 longitudinal cohorts; for each participant, we calculated a slope of an individual's global cognitive change from neuropsychological evaluations. We also performed a pathway-based analysis of the age-related cognitive decline GWAS. Results: We found no evidence to support the existence of a genomic region which has a strongly different contribution to age-related cognitive decline in African and European genomes. Known Alzheimer disease (AD) susceptibility variants in the ABCA7 and MS4A loci do influence this trait in AAs. Of inter

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