rs10863827 - HHAT
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827
ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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triglyceride levels Moderate
rs10863827 is associated with increased triglyceride levels in GWAS
Measure fasting triglycerides as part of cardiovascular screening
- GWAS_CATALOG:40436827
Diet
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limit refined carbohydrates and added sugars Moderate
Refined carbohydrates and sugars increase triglycerides; this variant increases triglyceride risk
Reduce refined grains, sugary drinks, and processed foods
- GWAS_CATALOG:40436827
Exercise
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regular aerobic exercise for triglyceride management Moderate
Aerobic exercise lowers triglycerides; important for this variant's elevated risk
150 minutes moderate-intensity or 75 minutes vigorous-intensity weekly
- GWAS_CATALOG:40436827