rs10859847 - FGD6
Magnitude 2.2 · 1 study on file
Reported associations
-
Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity - Unknown journal (n.d.) · Unknown authors · PubMed 32121467
ABSTRACT: Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected by chance. However, the aetiology and biological mechanisms underlying their comorbidity remain unknown. Here we examined the relationship between endometriosis and migraine using genome-wide association study (GWAS) data. Single nucleotide polymorphism (SNP) effect concordance analysis found a significant concordance of SNP risk effects across endometriosis and migraine GWAS. Linkage disequilibrium score regression analysis found a positive and highly significant genetic correlation (rG = 0.38, P = 2.30 × 10−25) between endometriosis and migraine. A meta-analysis of endometriosis and migraine GWAS data did not reveal novel genome-wide significant SNPs,
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
genetic risk for migraine and endometriosis Moderate
This SNP is associated with increased susceptibility to migraine and endometriosis in large cohort studies
review genetic findings and discuss preventive strategies and early symptom monitoring with healthcare provider
Screening
-
migraine symptoms and triggers Moderate
rs10859847-G is significantly associated with increased migraine risk in large GWAS
track frequency, intensity, and triggers of any migraine symptoms; discuss with healthcare provider