rs1085093 - NEDD8P1 - SAMD13

Magnitude 2.0 · 1 study on file

Reported associations

• A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men - PloS one (2010) · Zabaneh D, Balding DJ · PubMed 20694148

  ABSTRACT: We conducted a two-stage genome-wide association study to identify common genetic variation altering risk of the metabolic syndrome and related phenotypes in Indian Asian men, who have a high prevalence of these conditions. In Stage 1, approximately 317,000 single nucleotide polymorphisms were genotyped in 2700 individuals, from which 1500 SNPs were selected to be genotyped in a further 2300 individuals. Selection for inclusion in Stage 1 was based on four metabolic syndrome component traits: HDL-cholesterol, plasma glucose and Type 2 diabetes, abdominal obesity measured by waist to hip ratio, and diastolic blood pressure. Association was tested with these four traits and a composite metabolic syndrome phenotype. Four SNPs reaching significance level p<5×10−7 and with posterio

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