rs10849441 - PLEKHG6
Magnitude 2.2 · 1 study on file
Reported associations
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Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population - Unknown journal (n.d.) · Unknown authors · PubMed 23251661
ABSTRACT: Genetic variants responsible for susceptibility to obesity and its comorbidities among Hispanic children have not been identified. The VIVA LA FAMILIA Study was designed to genetically map childhood obesity and associated biological processes in the Hispanic population. A genome-wide association study (GWAS) entailed genotyping 1.1 million single nucleotide polymorphisms (SNPs) using the Illumina Infinium technology in 815 children. Measured genotype analysis was performed between genetic markers and obesity-related traits i.e., anthropometry, body composition, growth, metabolites, hormones, inflammation, diet, energy expenditure, substrate utilization and physical activity. Identified genome-wide significant loci: 1) corroborated genes implicated in other studies (MTNR1B, ZNF259
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Obesity risk assessment and prevention Moderate
rs10849441 G allele shows significant association with obesity risk traits
Discuss with physician for risk stratification and preventive strategies
Screening
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Weight and BMI monitoring Moderate
rs10849441 G allele is associated with increased obesity-related traits in GWAS
Monitor weight and BMI at least annually, more frequently if overweight