rs10847697 - SLC15A4

Magnitude 2.0 · 1 study on file

Reported associations

• Shared genetic study gives insights into the shared and distinct pathogenic immunity components of IgA nephropathy and SLE. - Molecular genetics and genomics : MGG (2021) · Zhang YM, Zhou XJ, Wang YN, Liu XZ, Wang YF, Lau YL, Yang WL, Zhang H · PubMed 34076728

  An autoimmune component has been suggested to play a role in pathogenesis of IgA nephropathy (IgAN). And genetic studies have reported the shared susceptibility loci between IgAN and the prototype autoimmune disease systemic lupus erythematosus (SLE). This study was designed to systemically identify and annotate the shared susceptibility genes between IgAN and SLE. We first conducted an imputation-based genome-wide association analysis in 1180 IgAN cases and 899 controls, 1639 SLE cases and 2410 controls. Then we integrated blood expression quantitative trait loci (eQTL) databases and gene expression data to prioritize the potentially functional genes. The results showed that a total of 1928 SNPs mapping to 14 loci were identified to be shared genes between IgAN and SLE. Conditional analys

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