rs10847444 - LINC02411 - LINC00508

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-wide association study of metachronous colorectal adenoma risk among participants in the Selenium Trial - Unknown journal (n.d.) · Unknown authors · PubMed 35815403

    ABSTRACT: Genetic variants related to colorectal adenoma may help identify those who are at highest risk of colorectal cancer development or illuminate potential chemopreventive strategies. The purpose of this genome-wide association study was to identify genetic variants that are associated with risk of developing a metachronous colorectal adenoma among 1,215 study participants of European descent from the Selenium Trial. Associations of variants were assessed with logistic regression analyses and validated in an independent case-control study population of 1,491 participants from the Colorectal Cancer Study of Austria (CORSA). No statistically significant genome-wide associations between any variant and metachronous adenoma were identified after correction for multiple comparisons. Howev


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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Screening

  • colorectal cancer surveillance protocol Moderate

    rs10847444 C allele is associated with 1.9-fold increased odds of multiple metachronous adenomas, indicating elevated cancer risk.

    discuss screening strategy with gastroenterologist; consider intervals more frequent than standard