rs10842987 - KLHL42 - RN7SKP15
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Emphasize low glycemic index carbohydrates Moderate
Genetic predisposition to glucose dysregulation is modifiable through dietary carbohydrate quality and portion control
Prioritize whole grains, legumes, non-starchy vegetables; limit refined sugars and processed carbs
Discuss with your doctor
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Genetic risk for type 2 diabetes and prevention strategies High
rs10842987 confers significant genetic risk for type 2 diabetes; early intervention may delay or prevent onset
Discuss genetic risk profile, family history, and diabetes prevention program eligibility (e.g., DPP-style intervention)
Exercise
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Regular aerobic and resistance exercise Moderate
Physical activity improves insulin sensitivity in individuals with genetic glucose dysregulation risk
150+ minutes per week moderate-intensity aerobic activity plus 2+ sessions per week resistance training
Screening
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Fasting glucose and HbA1c screening High
KLHL42 variant strongly associates with elevated fasting glucose (p=8e-23) and type 2 diabetes (p=2e-22)
Annual fasting glucose and HbA1c testing; establish baseline and monitor for trends
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Ophthalmology screening for diabetic retinopathy Moderate
Variant increases risk for type 2 diabetes with ophthalmic complications (p=4e-12)
Annual dilated eye exams starting at age 35-40 or if pre-diabetic/diabetic