Expressive

rs10838622 - CKAP5

Magnitude 2.2 · 1 study on file

Reported associations

  • Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. - American journal of human genetics (2018) · Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A, Hartwig FP, Evans DS, Joro R, Nedeljkovic I, Zheng HF, Zhu K, Atalay M, Liu CT, Nethander M, Broer L, Porleifsson G, Mullin BH, Handelman SK, Nalls MA, Jessen LE, Heppe DHM, Richards JB, Wang C, Chawes B, Schraut KE, Amin N, Wareham N, Karasik D, Van der Velde N, Ikram MA, Zemel BS, Zhou Y, Carlsson CJ, Liu Y, McGuigan FE, Boer CG, Bønnelykke K, Ralston SH, Robbins JA, Walsh JP, Zillikens MC, Langenberg C, Li-Gao R, Williams FMK, Harris TB, Akesson K, Jackson RD, Sigurdsson G, den Heijer M, van der Eerden BCJ, van de Peppel J, Spector TD, Pennell C, Horta BL, Felix JF, Zhao JH, Wilson SG, de Mutsert R, Bisgaard H, Styrkársdóttir U, Jaddoe VW, Orwoll E, Lakka TA, Scott R, Grant SFA, Lorentzon M, van Duijn CM, Wilson JF, Stefansson K, Psaty BM, Kiel DP, Ohlsson C, Ntzani E, van Wijnen AJ, Forgetta V, Ghanbari M, Logan JG, Williams GR, Bassett JHD, Croucher PI, Evangelou E, Uitterlinden AG, Ackert-Bicknell CL, Tobias JH, Evans DM, Rivadeneira F · PubMed 29304378

    Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to diagnose osteoporosis. To date, genetic variants in more than 60 loci have been identified as associated with BMD. To investigate the genetic determinants of TB-BMD variation along the life course and test for age-specific effects, we performed a meta-analysis of 30 genome-wide association studies (GWASs) of TB-BMD including 66,628 individuals overall and divided across five age strata, each spanning 15 years. We identified variants associated with TB-BMD at 80 loci, of which 36 have not been previously identified; overall, they explain approximately 10% of the TB-BMD vari

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Adequate dietary calcium Moderate

    CKAP5 variant linked to reduced BMD; adequate calcium is fundamental for bone mineral density.

    Target 1000-1200 mg daily from dairy, leafy greens, legumes, fortified foods, or supplements

Discuss with your doctor

  • Bone health strategy and osteoporosis prevention Moderate

    CKAP5 genetic predisposition to lower BMD warrants clinical discussion of prevention and monitoring.

    Discuss genetic risk, screening timing, prevention strategies, and medication options if indicated

Exercise

  • Weight-bearing and resistance exercise Moderate

    CKAP5 variant increases fracture risk through lower BMD; mechanical loading stimulates bone formation.

    150 min/week moderate-intensity or 75 min/week vigorous-intensity weight-bearing activity, plus resistance 2x/week

Screening

  • Bone mineral density assessment Moderate

    CKAP5 rs10838622 T-allele associated with lower bone mineral density, indicating genetic predisposition.

    Baseline BMD assessment recommended, particularly for those age 50+ (women) or 70+ (men)

Supplements

  • Vitamin D supplementation Moderate

    CKAP5 variant predisposes to lower BMD; vitamin D is essential for calcium absorption and bone health.

    1000-2000 IU daily, with target serum 25-OH vitamin D 30-50 ng/mL; test levels and adjust accordingly