rs10837649 - LRRC4C - LINC02741
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic diversity fuels gene discovery for tobacco and alcohol use - Unknown journal (n.d.) · Unknown authors · PubMed 36477530
ABSTRACT: Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries. Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in s
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic smoking initiation predisposition High
G allele at rs10837649 is strongly associated with increased smoking initiation risk in a very large-scale genome-wide association study.
Lifestyle
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Smoking initiation High
G allele is associated with increased genetic susceptibility to smoking initiation, which may be influenced by behavioral and environmental factors.
Implement behavioral prevention strategies such as counseling or support programs to reduce smoking initiation risk