rs10832337 - CALCB

Magnitude 2.2 · 2 studies on file

Reported associations

• A genome- and phenome-wide association study of plasma procalcitonin concentrations in individuals of European ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 41406505

  ABSTRACT: Summary Background Procalcitonin (PCT) is a biomarker used to differentiate between viral and bacterial infections, though the underlying mechanisms are not yet fully understood. This study aimed to identify genetic variants associated with plasma PCT concentrations and explore the associations of genetically predicted PCT with a wide range of disease related traits in a PheWAS. Methods We conducted GWAS and meta-analysis using data from the MDCS (n = 4007), MPP (n = 5097), and PREVEND (n = 3344) cohorts. We used fine-mapping to prioritise likely causal variants and explored regulatory effects using eQTL data, summary-data-based Mendelian randomisation (SMR) and colocalisation. To validate the PCT findings, we conducted multi-trait analysis of GWAS (MTAG) combining our results wi

• New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 34294844

  ABSTRACT: Migraine is a common disabling primary headache disorder that is ranked as the most common neurological cause of disability worldwide. Women present with migraine much more frequently than men, but the reasons for this difference are unknown. Migraine heritability is estimated to up to 57%, yet much of the genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate the etiology of this common disorder, we conduct a multiethnic genome-wide association meta-analysis of migraine, combining results from the GERA and UK Biobank cohorts, followed by a European-ancestry meta-analysis using public summary statistics. We report 79 loci associated with migraine, of which 45 were novel. Sex-stratified analyses identify three additional novel loci (CPS

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.