Expressive

rs10832256 - RRAS2 - COPB1

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association study - Unknown journal (n.d.) · Unknown authors · PubMed 37841410

    ABSTRACT: Introduction Epidemiological studies have consistently revealed that Vitamin D deficiency is most prevalent in Middle Eastern countries. However, research on the impact of genetic loci and polygenic models related to Vitamin D has primarily focused on European populations. Methods We conducted the first genome-wide association study to identify genetic determinants of Vitamin D levels in Middle Easterners using a whole genome sequencing approach in 6,047 subjects from the Qatar Biobank (QBB) project. We performed a GWAS meta-analysis, combining the QBB cohort with recent European GWAS data from the UK Biobank (involving 345,923 individuals). Additionally, we evaluated the performance of European-derived polygenic risk scores using UK Biobank data in the QBB cohort. Results Our st

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Serum 25-hydroxyvitamin D level High

    Genetic variant rs10832256 is strongly associated with lower circulating vitamin D levels

    Baseline measurement and annual monitoring

Diet

  • Vitamin D-rich foods (fatty fish, eggs, fortified milk) Moderate

    Dietary vitamin D sources help offset genetic predisposition to lower circulating levels

    Aim for 2-3 servings weekly of fatty fish or daily fortified dairy products

Lifestyle

  • Sun exposure for vitamin D synthesis Moderate

    UVB exposure triggers skin vitamin D synthesis; study identifies limited sun exposure as cause of deficiency

    Aim for 10-30 minutes midday sun several times weekly on exposed skin

Supplements

  • Vitamin D3 supplementation Moderate

    Genetic predisposition to low vitamin D may warrant supplementation if blood tests show deficiency

    Discuss with physician and dose based on serum 25-hydroxyvitamin D level