rs10832139 - RNA5SP331 - LINC02683

Magnitude 4.5 · 1 study on file

Reported associations

• Fifteen Genetic Loci Associated with the Electrocardiographic P-wave - Unknown journal (n.d.) · Unknown authors · PubMed 28794112

  ABSTRACT: Background The P-wave on an electrocardiogram is a measure of atrial electrical function and its characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave duration and P-wave terminal force traditionally have been used as markers for left atrial enlargement and both have been associated with increased risk of atrial fibrillation. Here, we explore the genetic basis of P-wave morphology through meta-analysis of genome-wide association study (GWAS) results for P-wave duration and P-wave terminal force from twelve cohort studies. Methods and Results We included 44,456 individuals, of which 6,778 (16%) were of African ancestry. Genotyping, imputation, and GWAS were performed at each study site. Summary level results were meta-analyzed centrally using invers

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