rs10831907 - TEAD1
Magnitude 2.2 · 1 study on file
Reported associations
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Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036
ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic risk for knee osteoarthritis Moderate
TEAD1 variant increases knee OA odds by 2.6 percent per allele; clinical discussion enables personalized prevention planning
Request consultation to review genetic risk and establish appropriate monitoring and preventive strategies
Screening
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knee imaging and monitoring program Moderate
TEAD1 rs10831907-A carriers have elevated genetic predisposition to knee osteoarthritis; early detection enables timely intervention
Discuss imaging schedule with healthcare provider, tailored to symptom status and other risk factors