rs10831551 - MIR4686 - ASCL2
Magnitude 4.5 · 1 study on file
Reported associations
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Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort - Unknown journal (n.d.) · Unknown authors · PubMed 29310926
ABSTRACT: Traditional linkage analysis and genome-wide association studies have identified HLA and a number of non-HLA genes as genetic factors for islet autoimmunity (IA) and type 1 diabetes (T1D). However, the relative risk associated with previously identified non-HLA genes is usually very small as measured in cases/controls from mixed populations. Genetic associations for IA and T1D may be more accurately assessed in prospective cohorts. In this study, 5,806 subjects from the TEDDY (The Environmental Determinants of Diabetes in the Young) study, an international prospective cohort study, were genotyped for 176,586 SNPs on the ImmunoChip. Cox proportional hazards analyses were performed to discover the SNPs associated with the risk for IA, T1D, or both. Three regions were associated wit
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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type 1 diabetes genetic predisposition Moderate
This SNP is associated with increased Type 1 diabetes susceptibility, particularly in individuals with high-risk HLA genotypes.
Screening
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baseline fasting glucose and HbA1c Moderate
Genetic predisposition to Type 1 diabetes warrants baseline metabolic assessment to establish reference values.
Obtain fasting glucose and HbA1c; discuss screening interval with provider