Expressive

rs10831475 - MAML2

Magnitude 2.2 · 1 study on file

Reported associations

  • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations - Unknown journal (n.d.) · Unknown authors · PubMed 34450027

    ABSTRACT: Summary Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before. We report thumb and spine osteoarthritis risk variants and identify differences in genetic effects between weight-bearing and non-weight-bearing joints. We identify sex-specific and early age-at-onset osteoarthritis risk loci. We integrate functional genomics data from primary patient tissues (including articular cartilage, subchondral bone, and osteophytic cartilage) and identify high-confidence effector genes. We provide evidence for genetic c

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Low-impact joint-protective exercise Moderate

    Regular physical activity preserves joint function and can reduce osteoarthritis progression risk

    150 minutes moderate-intensity or 75 minutes vigorous-intensity activity per week, emphasizing low-impact options like swimming, walking, cycling

Lifestyle

  • Maintain healthy weight for OA prevention Moderate

    BMI is a documented correlate of osteoarthritis risk; rs10831475 carriers show increased OA susceptibility

    Maintain BMI <25 kg/m2 if possible; consult healthcare provider for personalized targets

Screening

  • Osteoarthritis symptoms and joint health Moderate

    rs10831475 is significantly associated with osteoarthritis of the hip and knee with increased odds (OR=1.08, p=5.89e-12)

    Annual clinical assessment; early consultation if experiencing joint pain, stiffness, or swelling