rs10829959 - TCERG1L

Magnitude 2.2 · 1 study on file

Reported associations

• Longitudinal characterization of impulsivity phenotypes boosts signal for genomic correlates and heritability. - Molecular psychiatry (2025) · Deng WQ, Belisario K, Munafò MR, MacKillop J · PubMed 39181994

  Genomic correlates of impulsivity have been identified in several genome-wide association studies (GWAS) using cross-sectional designs, but no studies have investigated the molecular genetic correlates of impulsivity phenotypes using longitudinally constructed traits. In 3860 unrelated European participants in the Avon Longitudinal Study of Parents and Children (ALSPAC), we constructed longitudinal phenotypes for delay discounting and impulsive personality traits (as measured by the UPPS-P impulsive behavior scales) via assessment at ages 24, 26, and 28. We conducted GWASs of impulsivity using both cross-sectional and longitudinal phenotypes, estimated heritability and their phenotypic and genetic correlations, and evaluated their association with recently-developed polygenic risk scores (

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