rs10829439 - DOCK1
Magnitude 2.2 · 1 study on file
Reported associations
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Gut microbiota is associated with bone mineral density - Unknown journal (n.d.) · Unknown authors · PubMed 34779240
ABSTRACT: Aims Despite the interest in the association of gut microbiota with bone health, limited population-based studies of gut microbiota and bone mineral density (BMD) have been made. Our aim is to explore the possible association between gut microbiota and BMD. Methods A total of 3,321 independent loci of gut microbiota were used to calculate the individual polygenic risk score (PRS) for 114 gut microbiota-related traits. The individual genotype data were obtained from UK Biobank cohort. Linear regressions were then conducted to evaluate the possible association of gut microbiota with L1-L4 BMD (n = 4,070), total BMD (n = 4,056), and femur total BMD (n = 4,054), respectively. PLINK 2.0 was used to detect the single-nucleotide polymorphism (SNP) × gut microbiota interaction effect on
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Adequate calcium and vitamin D intake Moderate
DOCK1 variant affects bone density through microbiota-mediated pathways; adequate micronutrients support bone health
Aim for 1000-1200 mg calcium daily and 1000-2000 IU vitamin D daily
Screening
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Bone mineral density screening Moderate
DOCK1 variant interaction with Lactococcus affects femur BMD; baseline assessment identifies bone health status
Discuss timing of DEXA scan with physician based on age and risk factors
Supplements
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Lactococcus-containing probiotic supplements Moderate
DOCK1 variant rs10829439 shows significant interaction with Lactococcus genus in regulating femur bone mineral density
Consider fermented foods (kefir, yogurt) or Lactococcus-containing probiotics; discuss dose with healthcare provider