rs10829156 - ARL5B
Magnitude 2.8 · 1 study on file
Reported associations
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GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease - Unknown journal (n.d.) · Unknown authors · PubMed 21658281
ABSTRACT: Background Epidemiologic evidence suggests a heritable component to risk for sudden cardiac arrest independent of risk for myocardial infarction. Recent candidate gene association studies for community sudden cardiac arrests have focused on a limited number of biological pathways and yielded conflicting results. We sought to identify novel gene associations for sudden cardiac arrest in patients with coronary artery disease by performing a genome-wide association study. Methods Tagging SNPs (n = 338,328) spanning the genome were typed in a case-control study comparing 89 patients with coronary artery disease and sudden cardiac arrest due to ventricular tachycardia or ventricular fibrillation to 520 healthy controls. Results Fourteen SNPs including 7 SNPs among 7 genes (ACYP2, AP1G
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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cardiac evaluation for arrhythmia risk Moderate
Variant shows significant GWAS association with sudden cardiac arrest, suggesting altered cardiac electrophysiology or arrhythmia susceptibility.
Discuss with cardiologist about appropriate screening, including ECG, event monitoring, and imaging as indicated.