rs10828277 - CACNB2
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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regular aerobic exercise Moderate
Aerobic exercise reduces blood pressure through improved vascular endothelial function and is particularly beneficial for individuals genetically predisposed to elevated blood pressure.
150 minutes of moderate intensity activity per week, such as brisk walking or cycling
Screening
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diastolic blood pressure monitoring Moderate
CACNB2 calcium channel variants are associated with higher diastolic blood pressure in large epidemiological studies; periodic screening enables early detection.
Annual or biennial checks starting in adulthood; more frequent if baseline elevated